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  • The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help you manage chronic obesity in older adults with a body mass index (BMI) in excess of 27, provided that they also are afflicted by weight-related health problems such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder and as an aid to stopping smoking treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director from the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle including a reduced-calorie eating and working out, Contrave provides another treatment choice for chronic weight loss for people who are obese or are overweight and have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contains a reduced- calorie diet and regular exercising. Results from a clinical trial that enrolled patients without diabetes indicated that patients had a normal weight loss of four years old.1% in contrast to participants who have been given placebos) after a 12- month period, while an outside study involving patients with type 2 diabetes had an average weight loss of 2% over treatment with placebo at one year.

    Using two separate drugs to shed weight can be very effective there are combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the people that go through it one should err to the side of caution and allow FDA do its job and demand some study be done in order that the public knows the side effects and risks of the medications before we bring them. Keep in mind that drug companies will be in business to generate income and that they would say everything to keep people on his or her medications.

    Researchers found that participants using this drug to get a year, dropped a few pounds within a month and have kept the extra weight off during the entire 56 weeks in the study. Contrave is often a combination of the drugs naltrexone and bupropion, which usually reflect a fresh trend of weight-loss drugs which can be made up of multiple active ingredient, which can make them more potent and safer.

    Combo-pilling could be the newest fad or in addition to this the newest to come under scrutiny and thus it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills has become popular will be the fact that as of right now there aren't any long term prescription diet pills that have been licensed by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be authorized by the FDA.

    Seizures are a side effect with Contrave and must not be taken in those with seizure disorders. The drug can also raise blood pressure and heart rate, and must not be used in those with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy while using drug.

    The FDA also warned that Contrave can raise blood pressure and pulse rate and must stop used in patients with uncontrolled high blood pressure levels, and also by anyone with heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients having a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients on the increased likelihood of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.

    "There were no signs and symptoms of depression or suicidal thoughts in trial participants," said Fujioka.